Baylor college of Medicine (BCM) is a health sciences university within the Texas Medical Center, Houston, Texas. BCM recently developed a relationship with the Baylor-Scott-White Research Institute in Dallas Texas, consolidating research and clinical care across the state. The Human Genome Sequencing Center (HGSC) at Baylor College of Medicine was founded in 1996 under the leadership of Dr. Richard Gibbs and is a world leader in genomics, having previously developed whole exome capture (WES) and collaboratively pioneered the first clinical exome laboratory. The primary mission of the HGSC is actionable translational research across the full spectrum of human health and disease using large-scale genomic data to drive collaborative analytics, gene-phenotype discovery and clinical innovation. The HGSC is funded from multiple National Institutes of Health sources, including the Center for Common Disease Genomics (CCDG) and the electronic Research in Medical Records (eMERGE) programs, funded by the National Human Genome Research Institute (NHGRI).